It was concluded that vitamin E TPGS boost oral bioavailability of cyclosporine which is also a reversal agent of P-glycoprotein restricts activity thus P-gp or P-450 suppressors which decrease immune system in patients which was studied in healthy dogs. Amprenavir increases solubility, permeable which is a HIV protease inhibitor embellishes absorption when it interacted with Vitamin E TPGS agent. It was concluded that NSVs are safe have a ability to enter Caco-2 cell monolayer various transport system like intracellular uptake results PEGylated nanoparticles have no effect on Caco-2 cell monolayer which activates transcytosis pathway. Results demonstrated polyethylene oxide chains interact with bioadhesive properties of NSVs which can also pass through monolayer proved to increase transport systems across intestinal epithelial barrier. NSVs proved to be beneficial in patient compliance also as a innovative and promising nanocarrier for oral administration.